Phylogenetic inferences on HIV-1 transmission

Phylogenetic studies on the origin of HIV-1

In 1999, Edward Hooper proposed that the human inmunodeficiency virus type 1 (HIV-1) could have originated in the bathes of live oral polio vaccine (OPV). He claimed that this vaccine was produced in chimpanzee kidney epithelial cell cultures rather than in monkey kidney cell cultures, as stated by the producers of OPV at the Winstar Institute in Philadelphia. The vaccine was applied to about o...

Inference of Transmission Network Structure from HIV Phylogenetic Trees

Phylogenetic inference is an attractive means to reconstruct transmission histories and epidemics. However, there is not a perfect correspondence between transmission history and virus phylogeny. Both node height and topological differences may occur, depending on the interaction between within-host evolutionary dynamics and between-host transmission patterns. To investigate these interactions,...

Inferring HIV Transmission Dynamics from Phylogenetic Sequence Relationships

Perspectives D espite the range of resources directed at understanding the HIV pandemic over the past 25 years, surprisingly little is known about how HIV infection spreads through populations. Unlike some other infectious diseases, acute infection with HIV is difficult to identify. HIV disease most often manifests years after the transmission event. Together with the special challenges involve...

Social meets molecular: Combining phylogenetic and latent class analyses to understand HIV-1 transmission in Switzerland.

Switzerland has a complex human immunodeficiency virus (HIV) epidemic involving several populations. We examined transmission of HIV type 1 (HIV-1) in a national cohort study. Latent class analysis was used to identify socioeconomic and behavioral groups among 6,027 patients enrolled in the Swiss HIV Cohort Study between 2000 and 2011. Phylogenetic analysis of sequence data, available for 4,013...

HIV/AIDS Disease: Transmission Transition